Cordyceps Usage

There are traditional healers in Sikkim, Northern India, who advocate the use of the Cordyceps mushroom Sinesis for any and all illnesses. They suggest it as a tonic because they believe that it improves energy, appetite, stamina and libido as well as endurance and sleeping patterns.   Their use of the Cordyceps arose because it is a rare blend of caterpillar or ant and fungus and is found in Sikkim at altitudes over 3,800 metres.

Special Precautions – pregnancy and breastfeeding

There is insufficient solid information about the safety or otherwise of using Cordyceps if one is pregnant or breastfeeding.  The recommendation is therefore to avoid use.

Auto-immune diseases

Cordyceps might lead to the immune system becoming more active which could increase the symptoms of auto-immune diseases.  Such diseases are Multiple Sclerosis (MS), Rheumatoid Arthritis (RA), Pus (Systemic Lupus Erythematosus or SLE) and other conditions.  Someone suffering such a condition might be best avoiding Cordyceps usage.

Blood disorders

Use of Cordyceps could cause blood to clot more slowly.  As a consequence, taking Cordyceps might result in increasing the risk of bleeding in people with such blood disorders.


Cordyceps use could increase the risk of bleeding during surgery. The suggestion would be to cease Cordyceps at least two weeks before surgery.

Cordyceps might improve or increase the immune system.  If the immune system is increased, Cordyceps might have the effect that it decreases the efficacy of medications that decrease the immune system.  There is a list of medicines that decrease the immune system and these include:

Basiliximab (Simulect), Cyclosporine (Neoral, Sandimmune), Mycophenolate (CellCept), Azathioprine (Imuran),
Daclizumab (Zenapax), Muromonab-CD3 (OKT3, Orthoclone OKT3), Tacrolimus (FK506, Prograf),  Prednisone (Deltasone, Orasone),  Corticosteroids (Glucocorticoids), Sirolimus (Rapamune), and others.

Prednisolone is known to interact with Cordyceps.  The former drug can sometimes be used to decrease the immune system, and therefore Cordyceps use might make Prednisolone less effective in decreasing the immune system.

The health of a user, their age, health and other conditions will all determine what the correct dosage of Cordyceps should be.  At the time of writing, insufficient scientific data and information exist to allow the correct establishment of an appropriate range of doses for Cordyceps.  It is a fact that just because a product is natural does not make it safe and dosages can be critical.  Users should ensure that they follow the directions on product labels and packaging and also consult their pharmacist or doctor before use.